The best thing about Oniisama E is the mere fact that it is somewhat like Marmelade Boy. When I watched Marmelade Boy in it's entirity, I was shouting at the characters and I even through my jello cup at the screen. Much like that situation, I find myself talking back to the screen, this is most prevaliant when Saint Juste pops another pill or Nanako has a flashback about that steel garlic press that 'accidentally' fell on Saint Juste's hand. (because didn't you know, he's an ANGST MAGNENT! *D'OH HE"S A SHE I FORGOT!*)
Nanako's Father: Our Usually Talkative Nanako-chan doesn't tell us about her school life. Me: *screeches* THAT IS BECAUSE IT IS FUCKED UP!
Edit: RAZOR BLADES! *ahahaha* Oh yes, that's real subtle.
Edit 2: Emo girl has been allowed to have throwing knives, this bodes well for the series.